El Greco`s Burial Of Count Essays - Angels In Art, Toledo, Spain

El Greco`s "Burial Of Count" This painting is the Burial of Count Orgaz by El Greco (the Geek) his real name Domenikos Theotocopoulos. It hangs on the wall in the vestibule of the church of Santo Tome in Toledo, Spain and was painted in 1586. It is oil on canvas and was made to fit the very wall it hangs today. The painting does have a Round top making it a very odd fit for anywhere but the church for it to hang. The artist used many dark shades Blue and blacks with yellow and red in the items of importance and detail. White was very common. There was only one other color sort of hid in the robe of St Augastine,Green. He put alot of details in the things that he wanted the audience to pay attention to. The cross for example on the middle right, the keys to the gates of heaven held by saint peter on the top left and a nice touch with the priest with the skull on his rob on the bottom right. This is the first completely personal work by the artist. There are no longer any references to Roman or Venetian formulas or motifs. He has succeeded in eliminating any description of space. There is no ground, no horizon, no sky and no perspective. Accordingly, there is no conflict, and a convincing expression of a supernatural space is achieved. The painting has a couple of oddities with the boy pointing to the seal on the St. Stephen's robe but his other hand is sort of contorted. The faces of the people seem to be stuck here and there and don't seem to be natural flowing like a crowd should be in the mist of a vision .We get a glimpse of the artist above St Augustine's Hat as he looks up at his own art. And the boy is his son turns out to be his son. The painting is very clearly divided into two zones, the heavenly above and the terrestrial below, but there is little feeling of duality. The upper and lower zones are brought together compositionally (e.g., by the standing figures, by their varied participation in the earthly and heavenly event, by the torches, cross, etc. The grand circular mandorla-like pattern of the two Saints descended from Heaven echoes the pattern formed by the Virgin and Saint John the Baptist, and the action is given explicit expression. The point of equilibrium is the outstretched hand poised in the void between the two Saints, whence the mortal body descends, and the Soul, in the medieval form of a transparent and naked child, is taken up by the angel to be received in Heaven. The supernatural appearance of the Saints is enhanced by the splendor of color and light of their gold vestments. The powerful cumulative emotion expressed by the group of participants is suffused and sustained through the composition by the splendor, variety and vitality of the color and of light. The painting illustrates a popular local legend. In 1312, a certain Don Gonzalo Ruiz, native of Toledo, and Se?or of the town of Orgaz, died (the family received the title of Count, by which he is generally known, only later). He was a pious man who, among other charitable acts, left moneys for the enlargement and adornment of the church of Santo Tome (El Greco's parish church). At his burial, Saint Stephen and Saint Augustine intervened to lay him to rest. The occasion for the commission of the painting for the chapel, in which the Se?or was buried, was the resumption of the tribute payable to the church by the town of Orgaz, which had been withheld for over two centuries. All in all a very interesting piece of art. Though he is kind of a nock off of Michelangelo.

Statistic Chapter 2 Sample Question Essay Example

Statistic Chapter 2 Sample Question Essay Example Statistic Chapter 2 Sample Question Essay Statistic Chapter 2 Sample Question Essay Chapter 2 Study Guide MULTIPLE CHOICE QUESTIONS 1. The relative frequency of a class is computed by a. dividing the midpoint of the class by the sample size b. dividing the frequency of the class by the midpoint c. dividing the sample size by the frequency of the class d. dividing the frequency of the class by the sample size Answer: d 3. The sum of frequencies for all classes will always equal a. 1 b. the number of elements in a data set c. the number of classes d. a value between 0 and 1 Answer: b 5. A researcher is gathering data from four geographical areas designated: South = 1; North = 2; East = 3; West = 4. The designated geographical regions represent a. qualitative data b. quantitative data c. label data d. either quantitative or qualitative data Answer: a 7. A tabular summary of a set of data showing the fraction of the total number of items in several classes is a a. frequency distribution b. relative frequency distribution c. frequency d. cumulative frequency distribution Answer: b 9. If several frequency distributions are constructed from the same data set, the distribution with the widest class width will have the a. fewest classes b. most classes c. ame number of classes as the other distributions since all are constructed from the same data Answer: a 11. The sum of the percent frequencies for all classes will always equal a. one b. the number of classes c. the number of items in the study d. 100 Answer: d 13. The total number of data items with a value less than the upper limit for the class is given by the a. frequency distribution b. relative frequency distribution c. cumulat ive frequency distribution d. cumulative relative frequency distribution Answer: c Exhibit 2-1 The numbers of hours worked (per week) by 400 statistics students are shown below. Number of hoursFrequency 0 920 10 1980 20 29200 30 39100 15. Refer to Exhibit 2-1. The number of students working 19 hours or less a. is 80 b. is 100 c. is 180 d. is 300 Answer: b 17. Refer to Exhibit 2-1. The percentage of students working 19 hours or less is a. 20% b. 25% c. 75% d. 80% Answer: b 19. Refer to Exhibit 2-1. The cumulative percent frequency for the class of 30 39 is a. 100% b. 75% c. 50% d. 25% Answer: a 21. Refer to Exhibit 2-1. If a cumulative frequency distribution is developed for the above data, the last class will have a cumulative frequency of a. 00 b. 1 c. 30 39 d. 400 Answer: d 23. Refer to Exhibit 2-1. The number of students who work 19 hours or less is a. 80 b. 100 c. 200 d. 400 Answer: b 25. In constructing a frequency distribution, as the number of classes are decreased, the class width a. decreases b. remains unchanged c. increases d. can increase or decrease depending on the data values Answer: c 27. In a cumulative frequency distribution, the last class will always have a cumulative frequency equal to a. one b. 100% c. the total number of elements in the data set Answer: c 29. In a cumulative percent frequency distribution, the last class will have a cumulative percent frequency equal to a. one b. 100 c. the total number of elements in the data set Answer: b 31. A tabular method that can be used to summarize the data on two variables simultaneously is called a. simultaneous equations b. crosstabulation c. a histogram d. an ogive Answer: b Exhibit 2-2 A survey of 800 college seniors resulted in the following crosstabulation regarding their undergraduate major and whether or not they plan to go to graduate school. Undergraduate Major | |Graduate School |Business |Engineering |Others |Total | |Yes |70 |84 |126 |280 | |No |182 |208 |130 |520 | |Total |252 |292 |256 |800 | 3. Refer to Exhibit 2-2. What percentage of the students does not plan to go to graduate school? a. 280 b. 520 c. 65 d. 32 Answer: c 35. Refer to Exhibit 2-2. Of those students who are majoring in business, what percentage plans to go to graduate school? a. 27. 78 b. 8. 75 c. 7 0 d. 72. 22 Answer: a PROBLEMS 1. Thirty students in the School of Business were asked what their majors were. The following represents their responses (M = Management; A = Accounting; E = Economics; O = Others). A |M |M |A |M |M |E |M |O |A | |E |E |M |A |O |E |M |A |M |A | |M |A |O |A |M |E |E |M |A |M | a. Construct a frequency distribution and a bar graph. b. Construct a relative frequency distribution and a pie chart. Answers: a. and b. Relative MajorFrequencyFrequency M120. 4 A90. 3 E60. 2 O 30. 1 Total301. 0 2. Forty shoppers were asked if they preferred the weight of a can of soup to be 6 ounces, 8 ounces, or 10 ounces. Below you are given their responses. | 6 | 6 |6 |10 | 8 | 8 |8 |10 |6 |6 | |10 |10 |8 | 8 | 6 | 6 |6 | 8 |6 |6 | | 8 | 8 |8 |10 | 8 | 8 |6 |10 |8 |6 | | 6 | 8 |8 | 8 |10 |10 |8 |10 |8 |6 | . Construct a frequency distribution and graphically represent the frequency distribution. b. Construct a relative frequency distribution and graphically represent the relative frequency distribution. Answers: a. and b. Relative PreferencesFrequencyFrequency 6 ounces140. 350 8 ounces170. 425 10 ounces 90. 225 Total401. 000 3. A sample of 50 TV viewers were asked, Should TV sponsors pull their sponsorship from programs that draw numerous viewer complaints? Below are the results of the survey. (Y = Yes; N = No; W = Without Opinion) N |W |N |N |Y |N |N |N |Y |N | |N |Y |N |N |N |N |N |Y |N |N | |Y |N |Y |W |N |Y |W |W |N |Y | |W |W |N |W |Y |W |N |W |Y |W | |N |Y |N |Y |N |W |Y |Y |N |Y | a . Construct a frequency distribution and a bar graph. . Construct a relative frequency distribution and a pie chart. Answers: a. and b. Relative FrequencyFrequency No240. 48 Yes150. 30 Without Opinion110. 22 Total501. 00 4. The frequency distribution below was constructed from data collected from a group of 25 students. Height in InchesFrequency 58 633 64 695 70 752 76 816 82 874 88 933 94 992 a. Construct a relative frequency distribution. b. Construct a cumulative frequency distribution. c. Construct a cumulative relative frequency distribution. Answers: | | |a. |b. |c. | | | | |Cumulative | |Height | |Relative |Cumulative |Relative | |(In Inches) |Frequency |Frequency |Frequency |Frequency | |58 63 | 3 |0. 12 |3 |0. 12 | |64 69 | 5 |0. 0 |8 |0. 32 | |70 75 | 2 |0. 08 |10 |0. 40 | |76 81 | 6 |0. 24 |16 |0. 64 | |82 87 | 4 |0. 16 |20 |0. 80 | |88 93 | 3 |0. 12 |23 |0. 2 | |94 99 | 2 |0. 08 |25 |1. 00 | | | |1. 00 | | | 5. The grades of 10 students on their first manag ement test are shown below. |94 |61 |96 |66 |92 | |68 |75 |85 |84 |78 | a. Construct a frequency distribution. Let the first class be 60 69. b. Construct a cumulative frequency distribution. c. Construct a relative frequency distribution. Answers: | |a. |b. |c. | | | |Cumulative |Relative | |Class |Frequency |Frequency |Frequency | |60 69 | 3 | 3 |0. 3 | |70 79 | 2 | 5 |0. | |80 89 | 2 | 7 |0. 2 | |90 99 | 3 |10 |0. 3 | |Total |10 | |1. 0 | 6. You are given the following data on the ages of employees at a company. Construct a stem-and-leaf display. |26 |32 |28 |45 |58 | |52 |44 |36 |42 |27 | |41 |53 |55 |48 |32 | 42 |44 |40 |36 |37 | Answer: 2 | 678 3 | 22667 4 | 0124458 5 | 2358 7. Construct a stem-and-leaf display for the following data. |12 |52 |51 |37 |47 |40 |38 |26 |57 |31 | |49 |43 |45 |19 |36 |32 |44 |48 |22 |18 | Answer: 1 | 289 2 | 26 3 | 12678 4 | 0345789 5 | 127 8. For the following observations, plot a scatter diagram and indicate what kind of relationship (if any) exist between x and y. xy 27 619 39 517 411 Answer: A positive relationship between x and y appears to exist.

How does the applied math relate with the insurance field Assignment

How does the applied math relate with the insurance field - Assignment Example For example, when buying or selling an insurance policy, it is important for the two parties to understand the risks involved. These risks are analyzed, and their impact evaluated. This helps in determining the actual amount of the policy and the terms of payment. Secondly, mathematical techniques are used in analyzing utility curves. These curves are useful in determining how much a consumer is going to buy insurance for (Green, 96). In normal cases, the insuring firm has to charge the customer a fee more than the value of the risk. The utility curves thus help the insurance company determine the exact amount the customer is going to pay for the insurance. For example, if a consumer’s average loss per year for repairing his car is $10000, then the insurance company has to charge a fee above this figure for the insurance. This can only be achieved if mathematical techniques are used so as to calculate the actual profit percentage that the insurance company will charge. Thirdly, the insurance sector heavily relies on market research in the development of the various policies and understanding of the existing ones (Green, 97). Market research helps the insurance firms understand the best policies that will satisfy the demands of the market. For example, a company might want to study the market potential before developing a new insurance policy. In order to avoid losses, the company needs to have accurate information about the market. Mathematics is heavily applied in market research. For instance, random sampling can be employed by the insurance firms to understand various phenomenons in the market. In order to effectively collect, organize and analyze such data, mathematical techniques are required for accuracy. In particular, statistical methods are used in marketing research where variables such as standard deviation and variance help in the analysis of the collected data. Finally, applied mathematics is useful when it

W 3 OIS Essay Example | Topics and Well Written Essays - 250 words

W 3 OIS - Essay Example It is in line with this that a number of reviewers have looked at the implications of Moore’s Law, which advocates faster and cheaper computing in healthcare IT management. Firstly, the Center for Disease Control (2013) notes that Moore’s Law implies for healthcare managers to cut down cost on IT infrastructure by making use of cost effective IT so that there can be sufficient funds to cater for other components of the service. Secondly, Noe and Gerhard (2007) saw Moore’s Law as a revolutionary law in healthcare management that puts emphasis on the need to achieve more within a shorter period of time due to the speed of IT systems. By this and as healthcare managers do more within shorter time frame, efficiency can be guaranteed. Last but not least, the Center for Disease Control (2013) stated that Moore’s Law gives healthcare IT managers a challenge to resist any form of systems that cannot guarantee and secure easier execution of tasks. In effective, there should continue to be conscious efforts that promote user friendliness in the use of healthcare IT

Ethical Leadership Dissertation Example | Topics and Well Written Essays - 2750 words

Ethical Leadership - Dissertation Example The intention of this study is leadership as considered a core aspect in the functioning and success of n organization. Basically, ethics assists an organization in fostering good relations with the public and maintaining sales and good returns. Furthermore, ethics ensures that an organization operates according to the expectations of the public and maintains quality productions. In the past, organizations were basically faced with management problems due to the theoretical belief on the practice. However, due to the rising concern over leadership and its effectiveness, need for ethics arose. This led to the need for regulations of employees’ behaviors and decision within an organization. Level of competition has also increased and this led to emergence of unethical practices. This is because organizations were working towards gaining of competitive advantage unfairly. Intense competition in the market also led to emergence of technology in operation. This required organizatio ns to effectively evaluate their operation system and transform it to suit changes in operation so as to avoid losses and increase their market share and level of income in the long-run. However, ethical leadership is traced way back from Plato. This is because ethics emphasize on reputation and Plato was so much concerned with reputation. Furthermore, Chester Bernard traces the source of ethics to executive. This is because he spoke of executive responsibility which conforms code of morals. They are presently k

Health Essays Alzheimer Dementia Disease Essay

Health Essays Alzheimer Dementia Disease Essay Alzheimer Dementia Closing in on Alzheimer’s â€Å"Soon, Alzheimer’s disease will touch everyone in this country in some form or another, so the need to redouble our research efforts greater than ever before. We must have better treatments, earlier detection, and effective strategies to prevent Alzheimer’s. Scientists have made tremendous strides in the last two decades, but the clock is ticking.† -Samuel Gandy, MD, PhD, chair of the Alzheimer’s Association’s Medical and Scientific Advisory Council. There is no cure, but there is hope, for the world’s most leading cause of dementiaALZHEIMERS. â€Å"AD† is a neurodegenerative disorder, the underlying cause still being unknown. The clinical features or the underlying pathology can only be discovered on autopsy and thus the signs and indications of AD are instigated only after years of accretion of the credible causes. Some of the signs include:- Cognitive deterioration. Visual spatial confusion. Loss of recognition of persons and objects. Reduced mobility. Deterioration of muscles. Inability to feed oneself. Language disorientation. The onus of the illness lies in the deposition of fibrillized plaques containing amyloid beta(AB). The AB proposition shows potential for the reason that, as seen in patients with trisomy 21(downs syndrome), who have an additional copy of the gene for AB precursor, almost universally exhibit AD like indications prior to age 40. These signs of AD can be accredited to the cytotoxic potential of the mature aggregated amyloid fibrils. Consequently, a great amount of the research work on lead breakthrough is focused on:- Inhibition of fibrillization. Inhibition of AB precursor to AB. A different supposition understood to elicit the disease cascade, is centered on the effects of aggregated tau proteins. This speculation is sustained by the long standing observation that aggregation of AB plaques does not correlate with neuron loss. Although a great deal is known a propos the disease prognosis, causative or risk factors, the acquaintance we encompass of, in the present day, concerning the fundamental pathological origin or the core cause of the disease is zilch. Nevertheless, ApoE4, the foremost genetic risk factor for AD has been allied with surplus of AB build-up. The risk factors for AD are:- Advancing age. Head injury. Aluminum intake. ApoE4. Poor CVS health. Smoking. AD is most often established based on clinical signs and symptoms, and the history of patient’s infirmity, as a definitive diagnosis is only achievable by performing an autopsy. Common diagnostic tests include:- Memory testing. Intellectual functioning. Neuropsychological screening tests. Blood tests to rule out presence of other diseases. Functional neuro-imaging techniques like SPECT ad PET. Once diagnosed, on an average, survival is 7 – 10 years, the extremes being 4 years to 21 years. Essentials, statistics and incidence of Alzheimer’s:- 24 million people affected with AD worldwide. Slated to become 81 million by 2040. 1 out of 8 people above the age of 65 have AD. Only 19% with AD have the diagnosis recorded in their medical records. 7th leading cause of death in the United States. From 2000-2004, death rate due to AD has increased by 32.8%, while that of breast cancer, prostate cancer, stroke and heart disease has decreased by 2.6, 6.3, 10.4, 8% respectively. Costs of AD and other dementias amount to $148 billion annually. Current drugs in the global market for treatment of Alzheimer’s:- [1]ARICEPT: Key essentials about aricept: Was permitted for the treatment of mild to moderate Alzheimers by the FDA in 1996, and for the treatment of severe Alzheimers in 2006 Is the #1 prescribed Alzheimer’s drug—worldwide, more than 3.8 million people have been treated with Aricept. Aricept is a drug branded as a cholinesterase inhibitor. It is one of a group of prescriptions that appear to improve the cognitive ability (thinking, perception, judgment and recognition) in people with Alzheimer’s disease. Aricept can reduce behavioral troubles that may be exhibited by people with this type of dementia. Known as a cholinesterase inhibitor, Aricept delays the breakdown of the neurotransmitter acetylcholine in the brain. Acetylcholine helps communication between the nerve cells and is vital for memory. Side effects are typically mild and tend to disappear as treatment progresses. Common side effects are nausea, vomiting, diarrhea, fatigue, insomnia, muscle cramps. Less common effects are headaches and dizziness. Rare side effects are anorexia, gastric or duodenal ulcers, gastro-intestinal hemorrhage, bladder overflow obstruction, liver damage, convulsions, heart problems and psychiatric disturbances. [2]EBIXA: Ebixa fine points: Ebixa is one of a group of drugs called NMDA (n-methyl-D-aspartate) receptor antagonists. These receptors, along with the neurotransmitter glutamate, are implicated in transmitting nerve signals in the brain that may be imperative for learning and memory. Ebixa, which acts on NMDA receptors, facilitates to normalize transmission of nerve signals, and perhaps slow the decline of some indications of Alzheimers disease. Ebixa is not a cure for Alzheimers disease as it does not affect the fundamental degenerative progression of the disease. Ebixa may cause some unwelcome reactions. These may include fatigue, dizziness, sleepiness, headache, hypertension (high blood pressure), constipation, vomiting, anxiety, confusion, hallucinations and sleep disturbance. [3]EXELON: Exelon particulars: Exelon is one of a group of drugs known as cholinesterase inhibitors which is intended to treat symptoms in people with mild to moderate Alzheimers disease. Exelon works by reducing the breakdown of acetylcholine and thus escalating the amount of the chemical in the brain, a chemical thought to be vital for learning and memory. The prescription augments the action of acetylcholine by making the receptors it interacts with in the brain more responsive. Exelon is not a cure for Alzheimers disease as it does not affect the fundamental degenerative progression of the disease. Familiar side effects, in addition to nausea, vomiting, loss of appetite and weight loss, comprise of diarrhea, heartburn, stomach pains, dizziness, headache, weakness, fatigue and difficulty sleeping. A small number of people also experienced fainting. [3]REMINYL: Key specifics on reminyl: Reminyl ER is one of a group of drugs called cholinesterase inhibitors which is used to treat symptoms in people with mild to moderate Alzheimers disease. As of June, 2006, Reminyl became available only in the extended release (ER) format. It means that if you were taking Reminyl tablets twice a day prior to June 2006, you would now take a Reminyl ER capsule once a day. It augments the action of acetylcholine by making the receptors it interacts with in the brain more responsive. In the area of the brain first affected by Alzheimers disease, that dealing with cognition and memory, too little acetylcholine is available at the junctions between nerve cells to get messages across to the next nerve cell, The condition is helped, consequently, not only by preserving the acetylcholine from being destroyed by cholinesterase, but by making the receptors more responsive to the inferior amounts of acetylcholine. Reminyl ER is not a cure for Alzheimers disease as it does not affect the fundamental degenerative progression of the disease. probable side effects include: abdominal pain, diarrhea, indigestion, decreased appetite, difficulty swallowing, bleeding in the digestive system, weight loss, low blood potassium, low blood pressure, dehydration, seizures, agitation, aggression, hallucinations, weakness, fever, malaise, leg cramps, tingling in the hands or feet, ringing in the ears, headache, dizziness, tiredness, sleeplessness, runny nose, urinary tract infection, fainting or fluttering of the heart. INTERNATIONAL MARKET STATISTICS FOR DRUGS USED IN THE TREATMENT OF ALZHEIMERS:   BRAND GENERIC CLASS SPONSOR SALES in (million $) 2004 MARKET SHARE(approx) 2004 2005 Aricept donepezil CI Pfizer 1,266 1,580 58.10% Reminyl galantamine CI JJ 256 343 12.60% Exelon rivastigimine CI Novartis 320 340 12.50% Namenda memantine NMDAA Forest 5 247 9.10% Ebixa memantine NMDAA Lundbeck 28 86 3.20% Axura memantine NMDAA Merz 6 15 0.60% Cognex tacrine CI FirstHorizon 1 1 0.00% Others 87 107 3.90% TOTAL 1,969 2,719 100.00% Total Sales Figures = $2.7B (2005) with Aricept ®having 58% market share. DRUGS IN PIPELINE:- Name of the drug sponsor phase About the drug Data from previous phases. FLURIZAN Myriad 3 It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (AÃŽ ²42). Reduces the levels of the toxic amyloid beta 42 peptide through the allosteric modulation of gamma-secretase. FLURIZAN has completed Phase2 human clinical trial in 207 patients with Alzheimers disease. Phase 1 safety trial of FLURIZAN in healthy older volunteers identified no serious drug-related side effects. In nonclinical studies, FLURIZAN reduced the levels of the toxic peptide AÃŽ ²42 by approximately 70%, by modulating the action of gamma-secretase. Flurizan reduces amyloid pathology in the brain and prevents memory defects in transgenic mice. ALZHEMED Neurochem Inc. 3 Alzhemed is an oral small organic molecule that has been designed to interfere with the association between glycosaminoglycans (GAGs) and AÃŽ ² amyloid protein. It is thus thought to prevent GAGs from promoting ÃŽ ²-sheet and amyloid formation. Designed to prevent amyloid formation and deposition in the brain, and thus modify the course of AD. Alzhemed is expected to act on two levels: firstly to prevent and stop the formation and deposition of amyloid fibrils in the brain as well as to bind to soluble AÃŽ ², and secondly to to inhibit the inflammatory response associated with amyloid build-up in AD. Inhibit AÃŽ ² fibrillization and binds and reduces soluble AÃŽ ². VP025 Vasogen 1 Mediated via the regulation of microglial cell activation. Treatment with VP025 reversed age-related decreases in CD200 levels in the brain, reduced levels of microglial cell activation, and restored memory and learning function. Considerable amount of preclinical work has demonstrated: the ability of VP025 to reduce inflammation in models of a number of neurodegenerative diseases. the ability of VP025 to reverse detrimental neurological effects of chronic beta-amyloid exposure the ability of VP025 to reverse age-related inflammation in the brain AAB-001 Elan Pharmaceuticals, Inc., Wyeth. 3 Designed to bind and remove the AÃŽ ² peptide that accumulates in the brain. Immunotherapy approaches to the treatment of Alzheimer disease is based on the ability of antibodies raised against AÃŽ ² peptides to bind to and clear AÃŽ ² from the brain, thus removing the peptide and inhibiting the damage to neurons that AÃŽ ² inflicts. Anti-AÃŽ ² antibodies have been shown to prevent the accumulation of AÃŽ ² peptides in the brains of transgenic mouse models of AD (Shenk et al., 1999; Bard et al., 2000; DeMattos et al., 2001). In one clinical trial, patients immunized with AÃŽ ² peptide who actively generated anti-AÃŽ ² antibodies showed a significantly slower rate of decline in cognitive functions (Hock et al., 2003). Long-term follow-up studies of the patients who were involved in the failed phase 2a clinical trial of AN-1792 has shown that NTB (quality of life) scores remained significantly improved in antibody responders. In addition, CSF tau was significantly decreased in antibody responders (Gilman et al., 2005). Closing In on Alzheimer’s:- Lastly, fresh drugs tender genuine hope for repealing the malady. Concluding test outcomes will be out, for a complete novel generation of drugs designed to assault the fundamental basis of Alzheimers disease—medicines that propose, what one specialist calls legitimate, substantial, irrefutable hope for those with mild to moderate forms of the illness. Within three years, its nearly assured, well have disease-modifying drugs that fundamentally amend the nature of Alzheimers. From drugs which facilitate alleviation of merely the symptoms of the disease, we are now moving towards an era which will comprise of drugs that not only slow down the disease, but encompass the potential to wholly reverse it. Scientists are certain that one of the more than four dozen drugs now in human trials will succeed. One of the most hopeful of those, Flurizan, from Myriad Genetics, should complete its tests in the next 18 months. Exceedingly few drugs make it to Phase III clinical trials, the final stride before a drug goes to the FDA for authorization. Today, conversely, nine new Alzheimers treatments are in Phase III trials to test their effectiveness on a large number of patients. And dozens more are in smaller Phase II trials. This subsequent generation of drugs is deliberated to avert, obliterate and clean out deposits of beta-amyloid plaque that exterminate the brains nerve cells, leading to the distressing loss of memory, reason and, eventually, life that typifies Alzheimers. This optimistic information comes as the world awaits an epidemic of Alzheimers, the traumatic variety of dementia that Americans tell pollsters they dread more than heart disease, stroke or diabetes. Today, 5.1 million people in the United States suffer from the disease, but the supreme risk factor is age—the longer a person lives, the greater the likelihood—and in just four years millions of boomers begin to turn 65. One in eight people age 65 and older now has Alzheimers; half of those 85 and older have it. Connoisseurs say still if Alzhemed or another of these premature anti-amyloid drugs fails, that doesnt mean the amyloid theory is incorrect. It merely may mean that the drug didnt eliminate sufficient plaque to appreciably slow or arrest the disease. Finally, with the advent of such promising drugs into the market in the near future, there is potential to mitigate the humanity of the exorbitant fiscal burden due to the disturbing tempo at which Alzheimer’s is making headway. Keeping our fingers crossed might just help. References: http://www.myriad.com/alzheimers/flurizan.php http://www.vasogen.com/sec/vp025 http://www.alzforum.org/ http://www.alz.org/national/documents/PR_FFfactsheet.pdf http://www.alz.org/national/documents/PR_FFquotesheet.pdf http://www.medicinenet.com http://www.pharmaceutical-business-review.com http://www.theracarb.com/documents/investor_%20presentation.pdf http: //www.wikipedia.com

Macbeth: Contrasts of Nature :: Macbeth essays

Macbeth: Contrasts of Nature In the play, Macbeth, Shakespeare uses contrasts of nature in various ways. He consistently shows us that Macbeth and his wife's actions go against nature. The first lines of the play are a condensed version of the unnaturalness of things to come. "In thunder, lightning or in rain?" ( I, i, 2). In nature, thunder, lightening and rain occur together, but Shakespeare's use of the word "or" infers the unnatural occurrence of one without the others. "When battles lost and won" ( I, i, 4), is also not a natural occurrence. Battles are either lost or won. Shakespeare is implying the future opposites of nature in the forthcoming play. "Fair is foul, and foul is fair" (I, i, 11), further shows the use of inversions and paradoxs in nature that Shakespeare will use throughout the play. One of the main controversies of nature for the reader is that in spite of Macbeth's evil deeds, we still find him likeable. We see him in the same way that the King does when he welcomes him by saying, "O valiant cousin! Worthy gentleman" (I, ii, 24). We perceive him as valiant, because he is afraid of sacrificing his humanity. "My thought, whose murder yet is but fantasticle. / Shakes so my single state of man that function / Is smothered in surmise and nothing is / But what is not" (I, iii, 139-41). Macbeth has doubts about the predictions of the witches. He knows that it could be a trick and his misgivings make him seem to be a better person. Another thing that makes Macbeth likeable to the reader is the contrast with his wife. It is clear from her beginning that she is evil. She has reservations about Macbeth not being evil enough. "Yet do I fear thy nature" (I, V, 14). She fears he is too good to do the kind of evil deeds that she is planning. After Macbeth murders the King, he realizes the extent of evil that he has committed, but also realizes that the deed is done and there is nothing that he can do to rectify it. "As they had seen me with these hangman's hands / List'ning their fear. I could not say ‘Amen!' / When they did say ‘God bless us!'" (II, ii, 27-29). The fact that Macbeth is very troubled, and continues his tirade, "Will all great Neptune's ocean wash this blood / Clean from my hand? No, this my hand will rather / the multitudinous seas incarnadine, / Making the green one red" (II, ii, 59-62), evokes compassion for him from the

Reflective Account Essay

A new little boy started recently in nursery, as he entered nursery i bent down, smiled giving him eye contact i then said hello using his name and told him mine and he smiled back. He had never been to nursery before and he was very excited and had no awareness of the daily routine. i calmly held out my hand and he held out his. holding each others hands i showed him where his name card was, he picked up his name card and we walked over to the self-registration board. i asked him what he would like to play with and he chose to play with the cars. but during his play he become very upset because he wanted to play with the red car and another child had the red car. so i bent down and placed my arm around him and asked to look at me. Tears were rolling down his face and i explained to him that when the other child had finished playing with the red car he would be able to have a turn. i then sat down next to him to take turns in using the garage and sharing the cars. During the session i continued to support him, during lunch time and throughout the session. On occasions when he was unsure of what to do we went over to the routine board and talked him through the pictures so he knew what was happening next. Reflection I felt that i reassured him by letting him know who i was and at all times i made sure i gained his attention by using his name and ensure that he was listening by making sure we gained eye contact before speaking. I helped him with understanding the daily routine and I helped him with his social skills by supporting him with understanding the we need to take turns and share. Next time Next time I will carry on encouraging his social skills and communication skills by supporting him with sharing the toys and taking turns. I will also tell him the children’s names so he will feel part of a group and help with his self esteem. All while letting the child know I will be there to support him and help with his daily needs if he needs it.

A Brief Taste of Mexico essays

A Brief Taste of Mexico essays Aztec natives, who have been traced back thousands of years, originally inhabited Mexico. Despite their natural claim to the land, Hernn Corts was easily able to lead the Spaniards to conquer much of their territory in the 16th century. For this reason, it was Spain that maintained absolute control over Mexico, a gargantuan region that extended as far North as todays Oregon, and as far west as todays Texas. Between the years of 1750 and 1811, various Spanish monarchs ruled the territory. These rulers prevented revolution by strictly enforcing the separation of the inferior masses, denying any resistance opportunities. Although local white Mexicans (of Spanish decent) governed their respective colonies, it was the rulers back in Spain that controlled Mexico as a whole. Spaniards were a minuscule minority; however, until 1822, they used force and strategy to successfully exploit Mexicos resources in search of wealth. In 1811, rebel groups began to fight against their government. Distre ssed by the long war overseas, the Spaniards surrendered to the rebellion, allowing for Mexicos independence in 1822. From 1822-1841, Mexico attempted to use democracy, but the democratic system was misused; other than electing leaders, people still made few political decisions. In addition, leaders were constantly assassinated. In 1841, a lied war hero known as The Unsinkable Antonio Lopez de Santa Anna declared dictatorial power over Mexico, and backed by fearsome soldiers, he showed his Unsinkable side by refusing to lose his power. Santa Annas advantage lay in his large amount of supporters, allowing for better protection than previous leaders. The conservative leader lost his edge when Mexico lost land and lives to the U.S.-Mexican war. Benito Juarez, a liberal, overthrew Santa Anna in 1855. He gained support by writing a constitution, which called for a democracy based on equality. ...

Seven Golden Secrets of Creative Writing

Seven Golden Secrets of Creative Writing In the following quote, master of horror Stephen King hits the raw nerve of creative writing, the single most important step you need to take in your journey towards literary expression – absolute commitment. Without it, you could get lost in the dark, doomed to wander through the long night of literary anonymity like a navigator without a compass or the will to go anywhere.You can approach the act of writing with nervousness, excitement, hopefulness, or even despair†¦ You can come to the act with your fists clenched and your eyes narrowed, ready to kick ass and take down names. You can come to it because you want a girl to marry you or because you want to change the world. Come to it any way but lightly. Let me say it again: you must not come lightly to the blank page.Stephen KingThe blank page represents to great writers what Everest was to Edmund Hillary and Tenzing Norgay, what the Apollo 11 moon mission was to Neil Armstrong and Buzz Aldrin. It offers an extraordinar y journey to the uncharted regions of the imagination, a formidable challenge to the literary spirit of adventure within us. The problem is that writing creatively needs hard work and great commitment, and the vision to see a conclusion. I have developed the acronym W R I T E R S, which I hope will help you along that creative and adventurous road. It embodies seven golden rules of creative writing.W – where, who, what, when, whyIf you intend writing a book, a short story or even an essay, know exactly Where you are going. If you dont, you could end up going nowhere. When you know your direction use the other four Ws (Who, What, When, Why) to get there. Sketch a rough plan, just as an artist produces rough brush strokes to begin a work of art, and write down the essential ingredients of your story: the characters (WHO), the plot (WHAT), the direction (WHERE), the period (WHEN), the reasons (WHY).R – ResearchAdventure novelist Wilbur Smith, author of dozens of internati onal bestsellers, spends six months a year researching his subject before putting pen to paper. He then spends the next six months writing the book. Because his novels are usually based on real-life sagas, he manages to blend fiction with reality, giving life, energy and plausibility to his characters. Research your storyline and characters exhaustively. Know far more about your subject than you intend to write.I – Images and imaginationOne of the greatest aids to creative writing is the ability to think in images. Before you write it, see it in pictures; and if you can use your senses to strengthen the image, all the better. African locals living near Zambias Victoria Falls call it Mosi oa Tunya – the smoke that thunders, a wonderful description evoked by the sight and sound of this wonder of the world. When youre writing about characters, visualize them, hear them, smell them – your senses will be great accessories for your descriptions.T – TenacityCrea tive writing is not easy; it requires discipline and tenacity. Tenacity means finishing the project at all costs. One quality that separates great authors and the legions of writers of unfinished manuscripts is tenacity – the ability to continue even if you think your work will not succeed. James Joyce, whose book the Dubliners was rejected by 22 publishers, went on to write the best-selling English novel of all-time (Ulysses). So even if you think youre failing, carry on. One author I know wrote several books in a cellar. He climbed down a ladder into the cellar every day, his wife pulled up the ladder, and he stayed there writing until his wife let the ladder down later that day. Ive written 11 books and millions of words and it doesnt get easier – putting the first word down is like scaling the North face of The Eiger.E – EmpathySuccessful writing is all about grabbing the readers attention. Which means your words, characters, dialogue and construction must h ave empathy. Tie them into your own experiences. This does not mean dull-and-boring, long-winded sentences about yourself. It means incisive originality, directness and raw energy your readers can identify with. Let your writing come from the heart and write it straight. If your words are going to drive you to literary success, make sure theyre firing on all cylinders – empathy. Richard Carlson wrote his best-seller Dont Sweat the Small Stuff on a 12-hour Transatlantic flight. The book sold millions of copies because it was empathetic – millions around the world identified with his message.R – RealityThe great masters of fiction, George Orwell, John Steinbeck, Lewis Carrol and, more recently, Roald Dahl and Harry Potters J. K. Rowling captured the worlds imagination with characters that will live forever. The magic of their writing lies in the reality of their characters. So try to construct your characters with care, affection and detail. Build them up by writi ng notes about them – their personal idiosyncracies, their habits, their loves. When you write, go for the jugular – give your readers characters they will love; better still, give them characters drawn from the well of common, everyday human experience.S – SimplicityGreat writers know that simplicity is the bedrock of their craft. Short, clear sentences, short paragraphs, uncomplicated, direct constructions, and prose written from the heart are all you need. The Old Man and the Sea by Ernest Hemingway was a simple story about a fisherman and a fish, but it hooked millions of readers. The secret was in the simplicity of the dialogue and narration. Dont use long words to impress, and never be pompous or egotistical. Write with passion, music and simplicity – thats the real art of creative writing.

Dickens's Treatment of Education and Social Mobility Essay

Dickens's Treatment of Education and Social Mobility - Essay Example onal system as it existed for the children of the working class, but also to highlight some of the major problems inherent in the education of young gentlemen and even girls in terms of preparing them for the new economy that was emerging. Recognizing the societal shifts that were occurring, he also attempted to call attention to the crass tendencies of the newly rich or at least comfortable middle class, the overbearing and mostly ridiculous preening of the aristocracy and the desperate and uncontrollable situation of the poor. Limited in his scope for possible solutions, Dickens nevertheless included suggestions for reformation in his emphasis upon morality and nobility of spirit rather than the focus upon material wealth as a measure of means. Throughout his novels, Dickens criticized a society that could produce and hold in esteem any establishment that treated children with the cruelty of Dotheby’s Hall or Dr. Blimber. Yet he also criticized the useless education provided to the aristocracy as is illustrated in Pip’s gentlemanly tutoring. This would seem to suggest a general disdain for education altogether. However, through the gentle Fanny, who begs her father for an education and then educates herself further to help little Paul, to the finally repentant and thoroughly educated Pip, Dickens continues to underscore the need and importance of a true education. Dickens’ portrayal of the educational systems available for the poor, as well as the style of many of the private schools offering limited enrollment but similar systems of learning by rote, was highly critical and aimed at bringing the realities of education in England to the attention of the public. That he was successful in portraying an accurate representation can be seen in the fact that schoolmasters of England were frequently identified as the model of Mr. Squeers in Nicholas Nickleby: â€Å"While the Author cannot but feel the full force of the compliment thus conveyed to him, he ventures

Reaction paper Essay Example | Topics and Well Written Essays - 250 words - 6

Reaction paper - Essay Example That he was a former Jew and an insider makes what he is saying believable. There is no doubt that there are things about the World Wars that we are not aware of. Whether they were dispensable pieces of history or intentionally left out so as not to tarnish the image of the bloodshed in the Holocaust and to make those atrocities take an impact in the minds of people is something worth asking. What is very evident from the introduction of the speech was that it fully takes on an anti-Jewish approach or to say it directly, it is very anti-Semitic. â€Å"Here in the United States, the Zionists and their co-religionists have complete control of our government† (Freedman, n.p.). Benjamin Freedman tells us that what happened are all products of the propaganda of powerful Jewish people but I can’t stop feeling that in some way he has propaganda of his own. Throughout the speech he was very persuasive among Christians to take a second look at the lies Jews proliferated and how they have been kept in the dark all these years. Perhaps it was the best tone to convince people to what he is saying but the generalization of Jews makes it uneasy to take in without a second thought. It is very effective in that even I now begin to reconsider my knowledge of World War II and how it has portrayed Germany and rethink whether it was truly a genocide or just plain casualties of war.